Pendergrass's career began when he was a drummer for The Cadillacs, which soon merged with Harold Melvin & the Blue Notes. Melvin invited Pendergrass to become the lead singer after he jumped from the rear of a stage and started singing his heart out. Months later the group signed with Gamble & Huff on the then-CBS subsidiary Philadelphia International Records in 1972. The Blue Notes had hits such as "I Miss You," "Bad Luck," "Wake Up Everybody," the two million seller "If You Don't Know Me By Now" and many more. Following personality conflicts between Melvin and Pendergrass, Pendergrass launched a solo career and released hit singles like "The More I Get the More I Want," "Close the Door," "I Don't Love You Anymore," "Turn Off the Lights" and others.
His first solo album was self titled Teddy Pendergrass (1977), followed by Life is a Song Worth Singing (1978), Live Coast to Coast and Teddy (1979), 1980's TP and the final Philadelphia International Records album It's Time for Love (1981). He also sang a duet with Whitney Houston on "Hold Me", from her self-titled debut album.
On March 18, 1982, in the Germantown section of Philadelphia on Lincoln Drive, Pendergrass was involved in an automobile accident. The brakes failed on his 1981 Rolls-Royce Silver Spirit, causing the car to hit a guard rail, cross into the opposite traffic lane, and hit two trees. Pendergrass and his passenger, Tenika Watson, a transsexual nightclub performer with whom Pendergrass was casually acquainted, were trapped in the wreckage for 45 minutes. While Watson walked away from the accident with minor injuries, Pendergrass suffered a spinal cord injury leaving him paralyzed from the waist down.
After completing physical therapy, he returned to the studio to record the album Love Language, featuring the 1984 ballad "Hold Me", a duet with a then-unknown Whitney Houston. He also returned to the public for a performance on July 13, 1985, at the historic Live Aid concert in Philadelphia, then continued to record throughout the 1980s and 1990s. In 1996, he starred alongside Stephanie Mills in the touring production of the gospel musical Your Arms Too Short to Box with God. In 1998, Pendergrass released his autobiography entitled, Truly Blessed
Though generally inactive in his later years, Pendergrass' music would live on, inspiring and informing a younger generation of musicians and performers. “Wake Up Everybody” has been covered by a diverse range of acts from the British soul band, Simply Red to Patti Labelle and was even chosen as a rallying cry during the 2004 Presidential campaign by Kenneth Babyface Edmunds to mobilize voters. In addition, a number of Hip-Hop artists including Little Brother, Kanye West, Cam’Ron, Twista, Ghostface, 9th Wonder, DMX and Green Lantern have either evoked his name in their rhymes or informed their music with his samples.
In 2009, Pendergrass underwent surgery for colon cancer and had difficulty recovering from that disease from which he eventually died on January 13, 2010, at age 59, while hospitalized at Bryn Mawr Hospital in suburban Philadelphia.
